Discover a Skin Regeneration Serum That Redresses Skin's Declining Condition, Halts Inflamm-Aging & Gives Skin Aging a Refreshing Outlook

In the natural renewing cycle of human skin, cells are constantly being born, rising through the epidermal layers to the surface and falling off.

A young skin renews its surface layers every two to three weeks. Over time, as we age and our skin incurs the abuse of daily living (such as sun, stress, pollution), the cell turnover rate slows down causing the dead skin layer at the stratum corneum or surface to be thicker because old cells accumulate and stay on the surface longer. Tissue repair and cell regeneration slow down.

The flow of moisture from within also slows down resulting in dry lifeless uneven skin texture that's found in older-looking skin. We begin to notice those unwelcome signs of aging, including fine lines and wrinkles, loss of elasticity and loss of natural skin hydration and sagging.

Because collagen production is less, the skin becomes thinner. Collagen and elastin begin to break down, causing the skin to lose its flexibility and resilience. Skin cells are disorganized and malformed. Daily exposure to sunlight causes the amount of pigment in each cell to increase, producing freckles or age spots and uneven skin tone.

BIOSKINCARE is a 100% pure, natural skincare cream that utilizes a skin regeneration serum, created by a living creature to repair its own skin and even organs when damaged, to activate the skin's regenerative ability and speed skin cell renewal or turnover thus replacing dead cells by fresh cells pushed to the skin's surface, making the outer epidermal layer or stratum corneum smoother and naturally hydrated, thereby giving the skin a younger-looking appearance.

The cream is readily absorbed by the skin and stimulates skin regeneration without provoking any trauma, unlike most anti-aging or anti-wrinkle and exfoliation creams.

BIOSKINCARE boosts skin cell proliferation, leading to a much necessary thickening of the skin. In turn, a thicker skin layer results in a smoother appearance of the surface of the skin.

Freckles and age spots start to disappear. Pigment cells (melanin) are more evenly distributed, helping to prevent the appearance of new freckles and age spots – even scars that you have lived with a long time will appear softer and be less noticeable. The skin becomes richer in water holding molecules and in collagen and elastin that promote resilience and firmness. All these functions work together to keep skin look and be younger and healthier.

In the skin BIOSKINCARE

Increases cellular turnover of abundant, healthy keratinocytes, pushing fresh cells to the surface more quickly and promoting old cells to slough off faster

Increases calcium fixation by keratinocytes and thereby reinforces cell cohesion and improves the communication between keratinocytes

Regulates melanocyte production reversing and preventing hyperpigmentation

Promotes the even distribution of melanin, eliminating unwanted dark patches and age spots

Stimulates fibroblasts proliferation and activates scenescent fibroblasts the cells that give rise to collagen, elastin and the water holding molecules that retain moisture, resulting in stronger, more resilient skin

Increases GAG synthesis (water holding molecules, skin matrix components & intercellular messengers), providing natural hydration to the epidermis and dermis

Increases microcirculation and the formation of new healthy blood vessels, improving blood flow and oxygenation of the skin

Optimizes the skin's metabolism, the skin is more resistant and perfectly acts as a protection barrier against external aggressions

Acts as an oxidative-defense complex, scavenging free radicals and as an anti-inflammatory and immune modulating resource that boosts the immune system and enhaces the ability of the skin to withstand stress from UV solar radiation, pollution and wear and tear.

What is the beauty secret that makes this possible?

Stay alert for we guarantee you’ve never heard anything like it! And it may lead you to a lifetime of healthy skin.

BIOSKINCARE is made with the ONLY substance found in NATURE created by a little creature endowed with the ability to cope with (a) daily exposure to trillions of free radicals from a variety of sources: the sun's ultraviolet rays, pollution, harsh weather, and external stress while it thrives exposed nude to the sun rays and the hazards of the environment, pretty much like we merry around exposing our nude face; (b) keep its skin permanently moisturized, and; (c) regenerate its skin and even parts of some of its other organs whenever damaged.

To moisturize, protect, repair and achieve healthier cell regeneration this little creature produces a fluid that it bathes onto its skin. Scientific breakdown has characterized the fluid as a complex compound of glyco or sugar chain molecules bound to proteins, peptides, enzymes, co-enzymes and oligoelements with strong biological activity.

The same molecules are present in human skin when skin is injured, specially in younger people, where skin wounds heal quickly and without aberrant scarring, but are scarce or in inadequate proportions in adults.

We collect this fluid from live creatures of the Phylum mollusca, class gastropoda, species Helix Aspersa Müller, also known as the humble brown garden snail. Using proprietary technology, no harm is inflicted upon the snails during the labor-extensive gathering process.

It is this same substance that helps to protect the snail's body from oxygen radicals when it comes out of his shell after hibernating; from the effects of ultraviolet solar radiation; and from opportunistic micro-organisms always ready to intrude when skin is injured.

Also, what is far more interesting to us humans, it is the exact same fluid used by these little creatures, that happen to have a skin made of the same structural elements of human skin: —collagen, elastin, water holding molecules, etc.— to protect & repair their skin, organs and shell whenever they are damaged.

What Recent Science Says and Why Our Customers Rave?

Link: Skin Regeneration Properties of Mollusk Secretion Copyright © 2007 S. Karger AG, Basel

In this scientific report, some of the cellular and molecular effects underlying the observation that the snail secretions have regenerative effects on human skin are outlined. First, the secretion has enzyme antioxidant SOD (Superoxide Dismutase) and GST (Glutathione - often called the “master anti oxidant") activities as well as multiple modes of antioxidant action, acting at the level of free radical production and also sequestering free radicals. In addition, it stimulates fibroblast proliferation and rearrangement of the actin cytoskeleton.

Additional mechanisms involved in the regenerative effect of the secretion include the stimulation of extracellular matrix assembly and the action of regulatory proteins known as Tissue Inhibitors of Metalloproteinases (TIMPs) responsible for the reversible inhibition of metalloproteinase (MMP) enzymatic activities, which limits the extent of the damage during wounding and scar formation and attenuates the signs of aging by reducing the degenerative effects of excessive MMP activity.

Together, these effects provide an array of molecular mechanisms underlying the secretion's induced cellular regeneration and supports its use in regenerative therapy at the molecular level.

Clinical Trials

Two studies that provide clinical evidence of the positive effects of the snail serum on human skin are summarized here: the one below is on the effects of the snail serum on people affected by photo-aging and the one at the right hand column is about the effect of the ingredient on patients diagnosed with breast carcinoma, about to initiate or undergoing radiotherapy treatment

Evaluation of the Anti-Wrinkle and Reaffirming Efficacy of a Cryptomphalus Aspersa-based Product (CAS) in the Treatment of Skin Photoaging M.J. Tribó, E. Serra-Baldrich, M. Asin, J.A. Camarasa. Dermatología & Cosmética, March (vol IX), 1999.

Ultraviolet light as well as frequent contact with harmful environmental chemicals such as ozone leads to the formation of excessive quantities of reactive oxygen species on the skin. Free reactive oxygen radicals cause destruction of biomembranes by oxidizing unsaturated fatty acids and protein oxidation in human as well as depolarization and crosslinking of biopolymers. This induces a spectrum of well documented acute responses such as erythema, hyperproliferation, desquamation and with chronic irritation a general degradation of collagen together with an accumulation of abnormal elastin deposits in the dermis resulting in premature skin aging.

The skin’s own defense system is mainly based on an entire functionality of superoxide dismutase (SOD). Endogenic SOD is found at high levels in the stratum corneum but only low baseline levels were found in the dermis. In photoaged skin, a significant depletion of antioxidants enzyme expression was observed within the strateum corneum and in the epidermis. The endogenous level of SOD decreases significantly. A replacement by using cosmetic formulations is therefore a must. Externally applied SOD is able to penetrate into the intact stratum corneum and reach the upper layers of the epidermis, as has been shown using the fluorescent dye (FITC) labeled enzyme.

This report confirms a protective effect of the snail secretions in topical application against UV induced cutaneous damage and to overcome a lack of endogenic SOD to restore the antioxidative homeostasis of the skin.

The study focused on five aspects of skin aging due to excessive sun exposure.

A cream formulated with the snail serum was applied to the face of 32 individuals who showed signs of facial photoaging for an eight-week period on a continuous basis. The subjects were evaluated at 2, 4 and 8 weeks of treatment using a clinical evaluation method and the results were correlated with those seen with the use of instrumental techniques. Subjects also kept a subjective journal of their own observations and feelings towards the product which were evaluated at the end of the study.

The results of the study were very positive, affirming the snail serum as a true treatment in the fight against photoaging. Both according to the measurements taken by the instruments and image analysis programs, wrinkle depth is substantially aided by the product. Hydration is significantly improved due to the moisture retaining ability the serum imparts to skin.

Not only were the results processed by the instruments used to measure them positive, the subjects all had positive visual results, according to their journal entries. All study participants were happy with the topical treatment of photoaging in the study. Firmness, elasticity, and all the other side effects of excessive sun exposure were improved using the product with snail serum as a topical agent. Users' subjective comments indicate considerable comfort and satisfaction with the results of the experience.

Comments: the study was done in 1999 with the snail serum as part of a base cream that is different than the ingredients and technology we use in BIOCUTIS products which allows for a more deeper penetration of the serum into the skin and its proper release within the target cells.

The clinical efficacy of a cosmetic product is rarely confirmed by histological and immunohistochemical analyses. Our in-vivo studies with 15 women aged 35-65 of Fitzpatrick skin types II and III confirm that treatment with the snail serum leads to significant subjective (clinical signs and satisfaction) and objective (profilometry) improvements in cutaneous photoaging, confirmed by the improvement of subjects histopathological condition.

Testimonials

I have been using your BIOSKINCARE cream for 5 weeks. My skin is brighter, clearer, smoother....actually younger looking. Yes, I would say it has a glow.....and I'm hooked and just finished ordering more jars.  Deborah Cousins, Bennettsville, SC, USA.

I just wanted to post a brief testimonial about how I benefited from BIOSKINCARE.  After less than four months of use, I'm beginning to see dramatic improvements in my skin and complexion.  I had old acne scarring that has tremendously improved.  Also I had chronic folliculitis along my scalp that has completely vanished. Thanks. Frank Austin, NJ, USA.

I have had tremendous improvement on acne scars from your product.  I have had laser treatment and various other treatments to try and correct the problem and have had more improvement from the BIOSKINCARE than from a combination of all the rest.  I have left a message for an old friend who works for a plastic surgeon.  I can't wait to share my results with her.  I hope to get the word out on the benefits of BIOSKINCARE.  It seems that the endless hours of searching the web for some sort of miracle has paid off.  I don't know whether I'll ever have the flawless skin I've longed for but from the results I've seen thus far I may come pretty close.  I wish you, your family, and your co-workers a Happy and Healthy Holiday Season! Sincerely, Leslie Davis. Chicago, USA.

Originally purchased your product for my daughter for adult acne (small breakouts) and, after reading some of your testimonials, started using it myself for its benefit to older skin, primarily those small wrinkles and dullness. It does yield a healthier, younger appearance. Carol Jolly. NJ, USA.

This product has helped me to retain a clear, smooth & firm complexion despite my progressing age. Joan Erwin, New York City.

Just wanted you to know that my daughter who hadn't seen me since I've been using this product because she was attending school in Mexico, commented on how wonderful my complexion was looking. She asked what I was using and I told her. She has started using it and really likes the way it leaves her skin feeling. She, however doesn't have a skin problem. I also have another daughter that continually gets a skin condition on her hands and the doctors have never been able to figure out what it is or what causes it. A few weeks ago those bumps appeared on her hands again and I told her to try some of this cream. She put it on before she went to bed and the next morning it was gone and she hasn't had it again. Racine Lynch. West Virginia. USA.

I love this stuff... it clears my acne and it gives me a smooth, clear complexion......like nothing else I have ever tried. Jacqueline Hill. NY.

Excellent product! saw a difference almost immediately. Great for use under make-up. Makes skin look younger, brighter and smoother!!! Miss Uche Okoli. London.

Well, I tried it to heal deep burn like places on my face and in the delicate under-eye areas which I had to treat with effudex, a strong medicine to kill pre-cancerous spots. Next, a few small scars (old ones) as well as thin, dry prematurely aging skin wrinkles on face and neck. So far so good. Lots of peeling still but I don't mind that. I am noticing a slow and steady improvement and seems my skin is more elastic, thicker and clear. Many thanks! Sue Bowen, NY.

I love this product! I've been using it for six weeks now, two to three times daily. I've been very impressed with the results. I was horribly self-conscience because I have a few acne scars around my chin. They are much less visible after using the cream. Not only that, but I have noticed sun damage spots clearing as well, and my pores are so much smaller. My complexion hasn't looked this good in years! I have dreaded the coming of summer for a few years now, never wanting anyone to see me in direct sunlight due to the scarring. Now, I don't even think about it anymore. Such a boost of confidence. Thank you for creating this miracle cream!  Stacy. Peachtree City, Georgia, USA.

I have been using it for like 3 weeks now for my terrible sensitive and atopic skin. My skin is less sensitive, less dry. No more face rashes or pain. More clear, less frekles. I have notice an improvement in my wrinkles. Less noticeable. But most of all: one time in the morning and my face keeps soothed the whole day and night. It has not given me any rash at all. I am under new HRT (hormone replacement treatment) because of a histerectomy. I haven't tried it in my scar but probably I will. It was very hard for me to find the cream in Costa Rica. But as I found it I started using it. I am 45 going to 46 very white and atopic complexion and I can say I am happy with this product. Thanks. Maria Gabriela Hidalgo Costa Rica.

I am 36 years old and battle with adult acne. I have very sensitive skin which is easily dried out when I use over the counter acne products. I have tried every acne line out on the market. All I got was dry, flakey skin. When you are 36, you don't want to dryout/ wrinkle your skin anymore than you have too. I am extremely impressed with this product. Normally I have breakouts on a weekly (sometimes daily ) basis. Since using this creme, I have seen a drastic reduction in my breakouts - only three this past month!!!! Not only has it helped with the breakouts, it has also helped with the fine lines and has left my skin smooth and dewy looking. Thank goodness that a Google search exposed me to this product. I can not say enough about this creme. A true gift of mother nature. Thank you! Chris. Yaxley. NC, USA

My daughter bought BIOSKINCARE to try on her acne scars, she let me use it to see if I like it and we were amazed of the results, our skin looks more radiant than ever and the acne scars seem to be less noticeable, we will tell all our friends about it. Thanks! Elizabeth Aragon. New York.

This is order no. 3--send jars 5 and 6 quickly!! I have faithfully been using your BIOSKINCARE cream twice a day for the past 9 months. I love it and the way it has made my facial skin smoother, brighter, younger looking! Debora Cousins, South Carolina, USA

I really love the cream. This is my second order and I feel like it has helped the under-eye area to look younger and some of the acne scars on my face are beginning to fade. Helen Warren. TX, USA

I never try things like this, they always seem gimmicky (is that a word?) but last fall I ordered some on a whim. Ever since moving to Los Angeles, I have been breaking out. I think its the air quality here. But this stuff made my skin look like porcelain! I have been telling everyone about it, I love it! Chris Cl. West Hollywood, USA.

This cream is awesome. I have clear skin for the first time since before I was a teenager. I'm now 41. Hardly any wrinkles at all, everyone asks what my secret is. Stretch marks from 4 children are almost gone too. I used it on a small burn, no scar! It works great for the rosacea, keeps the redness down and seems to help the spider veins. It is fantastic for legs after shaving, no rash and no hair bumps! This product keeps it's word. I will advise my sister to try it.  D. Lewis. AL, USA

I want to thank you for a truly incredible product. I use your product every night after I cleanse my face. This is the first NATURAL product I have ever found that delivers on it's promises. It keeps my acne in check without drying out my skin which has been a real problem for me with several other acne treatments. I have extremely sensitive skin which has recurrent breakouts, but is also very dry and you product seems to help my skin find the proper balance. THANKS AGAIN AND GOD BLESS. Very Sincerely Yours, Jennifer Anderson. CA, USA.

I've been using your cream for over a year now and I can't believe the difference it has made. My skin looks great and those little wrinkles around my eyes have disappeared. Scarring from an operation last year are growing fainter all the time. I'm 45 and people guess I'm 35. Yeah!  Sh. Kirkland. MT, USA.

I am very satisfied with the product. I use it for scars and blemishes. My skin looks younger and the texture has improved a lot. Carla Martins. Ohio, USA.

I have been using the cream religiously. My scars were of keloid type and very disfiguring and source of tremendous embarrassment. I continue to see improvement not only in my scars, but also in the wrinkles around my eyes (crow's feet) and reduced laugh lines. I have recommended your product to my people and they are all passing the word on this miracle product! They are not words to convey my immeasurable gratitude to you for making this unique product available at a reasonable price. Keep on the good work! CRH in San Diego, California. USA.

Excellent product for scars and wrinkles. I have been using your product for 3 months now, and the results are quite astounding. I am actually ordering for friends now, as you can tell by the number of orders I have placed with you in the last three months. Thank you for a great product. Cameron Templar. NY, USA.

I love this stuff. Has helped dramatically! Skin was never clearing up and now it is smoother and more even toned...significantly helps overnight to wake up looking fresher and clearer. Moose Jaw. Canada.

This product works excellent. I love the way it makes my skin feel! I now have my mom and brother using it. I originally ordered it for my brother who has acne and was constantly trying different things to help alleviate it. One day I was surfing the web and came across your site, and it sounded to good to be true. We all see a difference in our skin. The healing properties in your product are amazing! Thank you. Sincerely, Melissa Shelly. PA, USA.

After only one month of using the creme my scars are getting thinner, less redness, softer and lighter. We'll see how they keep progressing. I'm ordering the second jar right now. Serena Buschi. NY, USA.

Your product is nourishing and makes skin appear radiant. BIOSKINCARE is promising to even a skeptic like myself, who has tried many treatments. Christa Wusinich. PA, USA.

I love your product and will keep using it. It cleared my complexion, reduced the appearance of minor flaws and my skin feels softer and looks younger. Nancy Grilz. MN, USA.

I have used this product and it is great for the lines above the lip. The lines have disappeared. And it is great for the wrinkles under and around the eyes. Patricia Ciccone. PA, USA.

Myself and my daughter have been using your cream for about a month now and already my skin feels smoother and my daughters acne is gone, although she still has the acne scars they are definitely fading. My daughter also uses it for a five inch scar on her leg which is also showing noticable improvement. Thank you for a wonderful product! Diane Sandison. Newcastle Upon Tyne, United Kingdom.

I love your product! I've tried tons of expensive and allegedly useful treatments for acne and acne scaring like clearlight, microdermabrasion, intense pulsed light and various costly beauty products but none have had the same effect so quickly as this miracle in a jar! I'm only 1/2 way through my first jar and 90% of acne has cleared and about 60% of acne scars are fading away. Thank you! I am totally bowled over by your product! Sharon Lee. London.

I have been using the cream for about 7 weeks now and I love it. I have noticed a reduction in my deep cystic acne scars caused by to 30 years of acne breakouts. I have had in the past 2 dermabrasions and several chemical peels, years of glycolic acids which reduced the scars somewhat but the cream is definitely working better than all those methods. It has such a calming soothing effect in general on the skin that compares to nothing else I have come across in my search. I believe that it will take time, perhaps about a year, for them to heal at the rate it is going. (...)  I am so grateful ad that I found BIOSKINCARE! Irene Sowton. CA, USA.

Skin Renewal & Regeneration

The skin is a continuously self-renewing organ, with a complex, multilayered kinetic organization. The epidermis contains mainly keratinocytes, along with a minor population of dendritic cells, stem cells, and possibly a pool of quiescent cells (a dormant reservoir).

Tissue stem cells are responsible for replenishing and maintaining a population of cells which make up a functioning organ. They divide by asymmetric cell division where one daughter remains a stem cell while the other daughter becomes a transit cell, which divides a defined number of times and differentiates. A fully differentiated cell has a finite life-span. A tissue can be maintained by various strategies. Stem cells can divide often and differentiated cells die often (fast turnover). Alternatively, stem cells can divide infrequently, and the differentiated cells are long lived (slow turnover).

Genetic alterations and mutations can interfere with tissue homoeostasis. Mutations can induce senescence and apoptosis, and this can result in a reduction of the number of functioning tissue cells which could correlate with tissue aging. Alternatively, mutations can result in the carcinogenic transformation of cells and the formation of a tumour.

Keratinocytes originate in the basal layer of the epidermis, through division of a population of stem cells. The daughter cells then divide several times as transit amplifying cells, which lose proliferative capacity and differentiate into post-mitotic, keratin-rich cells as they migrate upward to the spinous layer of the epidermis. As these cells continue their transit through the granular layer, they become anucleate and form the uppermost, cornified layers which ultimately are sloughed off. Turnover of the epidermis allows the organ to maintain its barrier function, repair injured skin in wound healing, and respond to stimuli that promote or inhibit cell proliferation.

Skin aging

Many factors, both extrinsic and intrinsic, cause the skin to age. Those causes can easily be divided into three main categories: biological or intrinsic aging, environmental aging, and mechanical aging. Let's look at each cause individually to understand ways they can be minimized.

Biological or intrinsic aging is the result of changes—often genetically determined—that occur naturally within the body. Everyone has a biological clock or chronological age determined by genetic makeup. This applies to the skin as well. As our biological clock ticks, our skin gradually loses its ability to function as it once did. Biological aging occurs as a result of natural changes within the body that manifest themselves in outward signs of aging on the skin.

Frequently, changes associated with biological aging are the result of a gradual shift in the balance of certain hormones and messenger molecules excreted by other glands and organs within the body. Many of these changes are genetically determined and cannot be stopped.

The most obvious sign of intrinsic aging is a decrease in the overall thickness of the epidermis as a whole, with a reduction in the number of cell layers. The number of cells in the stratum corneum does not diminish with age, however; this is important, because of the vital role of this layer as the skin barrier. On the other hand, the numbers of melanocytes and other cells do decrease with age. So do the numbers of the Langerhans cells, which are involved in the body's response to allergens. This could be one reason why people tend to experience fewer allergic reactions as they get older.

The rete pegs become less prominent, and the junction of the dermis and epidermis becomes flattened. This means that the epidermis is not so securely held down, and becomes more vulnerable to damage by friction. Metabolism in the skin (as everywhere else) slows down. So too does the rate at which epidermal cells are produced, which may interfere with wound healing. The time necessary to repair the stratum corneum barrier increases considerably with age: the replacement of skin cells takes about twice as long for people over 75 as for those around 30.

Although the sebaceous glands themselves do not change much with increasing age, sebum production declines in many older people, especially after the age of 70, though the glands on the face actually enlarge in people of much older age.

With age, the number of active sweat glands falls and their output of sweat decreases too. As a result, perspiration is less in elderly skin. This explains why older people often find it hard to adapt to hot weather.

Most older people have a dry skin and therefore have a special need to avoid the over-use of harsh soaps and detergents, in order to prevent problems associated with dryness. Aged skin retains its fundamental ability to control water loss, but may partially lose this ability if the stratum corneum barrier becomes damaged by physical or chemical agents. Many substances will penetrate aged skin more easily than young skin.

Fortunately, some of the factors contributing to biological aging can be controlled. Scientists are beginning to understand how free radicals (unstable molecules) damage proteins, lipids, and the DNA within cells, and, in turn, accelerate the biological aging process. Antioxidants are molecules with the ability to neutralize free radicals in the skin. A healthful diet full of antioxidant-rich fruits and vegetables, along with nutritional supplementation and topical application of key nutrients, may help decrease the intensity and delay the onset of many changes that are a result of biological aging.

The second category of factors that cause the skin to age are all results of extrinsic sources in the environment. Environmental aging occurs as a result of daily exposure to trillions of free radicals from a variety of sources: the sun's ultraviolet rays, pollution, smoke, harsh weather, and external stress. These free radicals damage lipids, proteins, and DNA, all of which limit the ability of cells to function and cripple the integrity of overall cell composition. Years of accumulated environmental stress on cellular structures results in the premature aging of the skin.

Sun exposure is the primary environmental stressor leading to damaged skin. The damage to skin components caused by both prolonged and incidental sun exposure is called photoaging. Although cigarette smoke, exposure to harsh weather conditions, and pollution are prolific contributors to environmental aging, UV damage from the sun's rays accounts for 90 percent of premature skin aging. Photoaging damages collagen, elastin, melanocytes, and the moisture barrier, resulting in wrinkles, sagging, uneven skin tone, dark spots, and a rough, dry skin texture.

While sun exposure is the environmental stressor that accounts for most premature skin aging, there are others. Pollution damages skin by increasing free radical production and increasing the effects of UV radiation. Harsh weather (dry air, wind, and cold) depletes skin of essential moisture, resulting in a rough texture and fine, dry lines. Cigarette smoke increases free radical production and may decrease collagen and elastin production. Cigarettes also significantly decrease the supply of oxygen to skin cells.

The third category of aging is called mechanical aging. Mechanical aging is the result of continually repeated wrinkle causing behaviors, muscle movements repeated day after day and year after year. Although it is unrealistic to avoid some wrinkle causing behaviors such as smiling and frowning, the following behaviors should be avoided to help prevent premature signs of mechanical aging:

Squinting.

The thinker stance (resting chin or cheek in the hand).

Sleeping on your side or stomach.

Scrubbing with hot water.

Weight fluctuation.

Unbalanced diet and lack of sleep.

Pursing the lips while smoking or drinking from a straw.

Evidence of Aging: Changes in Physiology
Skin aging results from the deterioration of structures in the skin and the slowing of healthy skin functions. Let's take a closer look at several of the visible signs of skin aging and what is happening inside the skin to cause these changes.

Dry skin is a visible sign of skin aging. Healthy, young skin maintains appropriate moisture levels through the sealing properties of the moisture barrier, which is composed of keratin-filled keratinocytes (skin cells) surrounded by and sealed together with interspersed epidermal lipids (ceramides, lipids, and fatty acids). As we age, the skin produces fewer ceramides, lipids, and fatty acids to seal the moisture barrier, resulting in an increase in transepidermal water loss and dryness.

A natural decline in hormone levels is usually the cause of this decreased production; however, several other preventable factors can also strip epidermal lipids, causing excessive dryness. Consider the following:

Improper skin care. Using harsh cleansers and neglecting to supplement the skin with rich, nourishing moisturizers.

Harsh weather conditions. Enduring extreme temperatures and wind without adequate moisturizers and protection.

UV radiation. Neglecting to protect skin from the sun's UV rays with sunscreen.

A dull, rough complexion is another visible sign of skin aging. Healthy, young skin remains smooth and radiant because fresh, new cells are brought to the surface as older cells are continuously shed. The skin cells in the bottom layer of the epidermis (stratum basale) constantly divide through cell division, forming new keratinocytes. This regenerative process is called skin cell renewal. As we age, the rate of skin cell renewal decreases, causing cells to become more sticky and not shed as easily. As a result of cell renewal decreasing, the skin becomes thinner and more susceptible to environmental damage, especially photodamage from the sun's UV rays. Eventually, the skin appears dull and rough in texture.

Several factors contribute to the process of skin cell renewal declining as we age. For example, weakened blood vessels in the dermis and a flattening of dermal papillae decreases the surface area between the dermis and epidermis across which nutrients can diffuse. This process decreases nutrient and oxygen supplies to the basal cells in the lower epidermis. UV exposure can also penetrate the epidermis, damage basal cells, and slow the rate of cell division. Finally, failure to exfoliate the surface of the skin with physical and chemical exfoliates for the purpose of smoothing the skin and stimulating cell renewal contributes to the decline in renewal.

A third visible sign of aging is fine lines and deep wrinkles in the skin. The structural protein called collagen, which is found in the dermis, provides a mesh-like framework of support and strength for the skin. As we age, collagen production decreases and collagen fibers degrade at a faster rate than in earlier years. This results in an overall decrease in the amount of collagen in the dermis. Areas with less support begin to cave in and wrinkles begin to form.

Multiple factors lead to decreased collagen levels. First, with age there is a natural decline in messenger molecules that trigger collagen production. There is also an increase in the enzyme collagenase which breaks collagen down. Another factor contributing to decreased collagen levels is free radicals from UV exposure. These can damage collagen strands and stimulate collagenase activity, which leads to the formation of irregular collagen linkages that weaken the skin. In order to avoid UV damage to collagen fibers and fibroblasts, application of a consistent daily sunscreen is necessary. Research also indicates that chemical exfoliation may stimulate collagen production.

The following are factors that decrease collagen levels in the skin:

UV rays can penetrate the skin and cause damage to collagen-producing fibroblast cells.

Mechanical stress on the skin caused by repeated wrinkle causing behaviors can also break down collagen.

With age, the synthesis of glycosaminoglycans (GAGs) decreases, affecting moisture levels in the dermis; collagen becomes brittle and prone to breakage.

As skin renewal decreases, wounds heal more slowly and the skin thins, becoming more susceptible to environmental stressors; this can lead to damaged fibroblasts and a decrease in collagen levels.

Loss of firmness in the skin is another evidence of aging. All three types of skin aging—biological, environmental, and mechanical—contribute to the skin's loss of firmness. Biologically, our body naturally produces more of the hormone DHT as we age. As DHT levels increase, elastin production is inhibited. Elastin is another skin structural protein found in the dermis. This coil-like protein has the ability to snap back into place after stretching, giving the skin its elastic quality. As we age, elastin fibers lose much of their resilience and elastin production within the fibroblasts decreases. This overall decline in healthy elastin levels results in areas of decreased firmness, especially along the jaw line, neck, and around the eyes.

Environmentally, UV rays can penetrate the skin to damage elastin-producing fibroblast cells. Also, as skin cell renewal decreases, wounds heal more slowly and the skin thins, becoming more susceptible to environmental damage. This can lead to damaged fibroblasts and decreased elastin levels. Finally, mechanical stress, due to repeated wrinkle causing behaviors, can permanently stretch out elastin fibers.

Enlarged pores are also a sign of aging skin. To a large degree, pore size is determined by genetics; however, as we age, our pores tend to appear larger. The pore's enlarged appearance is due to a buildup of dead cells around the pore. As more collagen breaks down and production slows, the supportive structures surrounding cells decrease and cells can appear stretched. Keeping the skin exfoliated and the pores clear will help reduce the appearance of pore size. Also, consistently using a sunscreen to protect collagen helps maintain pore size.

Age spots are the last evidence of aging that we're going to discuss. Normal skin pigmentation helps protect healthy skin from the stress of mild UV exposure. Melanin, the skin's photoprotective pigment, is produced in specialized melanocyte cells in the lowest layer of the epidermis (stratum basale). As we age, melanocyte activity decreases, making the skin more susceptible to UV damage. With age, melanocytes also tend to cluster together. This results in patches of pigmentation called age spots.

Many factors contribute to the production of age spots. First, hormone imbalances that occur with advanced age result in fewer melanocytes and can also trigger excessive melanin production. Second, UV light rays stimulate melanocytes to produce skin pigment. UV light can also penetrate the skin and damage melanocyte DNA, which can stimulate melanocytes to enlarge and cluster together. Third, as the cell renewal cycle decreases, wounds heal more slowly and the skin thins, becoming more susceptible to environmental damage. This can lead to damaged melanocytes and abnormal pigmentation. Finally, poor skin care habits can lead to skin irritation, which triggers melanin production.

Prevent Premature Skin Aging with Proper Skin Care
The majority of premature, avoidable skin aging is caused by UV radiation; thus, it is absolutely essential to use a sunscreen. Even if you aren't in the sun for extended periods, effects of incidental sun exposure accumulate and show up on the skin.

Fortunately, you can turn back the clock on your skin. Even if you did not properly care for your skin in years past, we can help repair sun damage and reverse some of the effects of both biological and mechanical aging. Because youthful, healthy skin portrays confidence and beauty, we are all concerned with what we assume is inevitable skin aging. The good news is that we have more control than we realize over the rate at which our skin ages. Maintaining youthful skin starts with good skin care.

Over the years, and specifically between the ages of 25-30, the cell renewal process slows down. This means our skin starts to look dull, with an uneven thickened texture. In some cases, our complexion can look uneven, because dead skin cells build up on the surface. However, even before the age of 30 our skin needs exfoliating action: a metropolitan lifestyle and contact with pollutant particles can negatively affect cell turnover.

Air pollution not only threatens our health but also our looks!

Every day, air pollution attacks plants and buidings – and for sure, our skin. The presence of oxides, hydrocarbons and particles of heavy metal, particularly iron, blocks normal epidermal respiration, damaging the skin’s natural protective film and promoting the production of free radicals, which accelerate cell aging.

This is why the number of people who suffer from hypersensitivity and allergies – even at a young age – continues to rise.

Delicate, vulnerable skin with a tendency to redden easily; problems with fragile capillaries, irritability or even allergies. Dry, dehydrated skin, in some cases with a tendency towards oiliness.

These are the characteristics of hypersensitive skin, and dermatologists have noted a constant increase of people with this kind of skin.

This is why BIOSKINCARE is indispensable not only for mature skin, but also for younger skin. Its ENZYMES purify the skin, getting rid of harmful substances. And it improves the flow of oxygen to the skin and stimulates cell metabolism, neutralizing the corrosive effect of pollutants, stimulating cell respiration and slowing down the skin’s aging process, which also yields an anti wrinkle effect.

Skin Cells Converted to Stem Cells

Our bodies continue to grow along that developmental continuum once we are born, and there is a continual need to replenish worn out or damaged cells. In the infant and even in the adult, there remains a reservoir of stem cells in many tissues. These cells are more limited in their scope of development; termed "pluripotent" or "multipotent" stem cells, because they can replenish themselves and can contribute to formation of specific cell types in multiple tissues.

A simple example are the stem cell which make our skin (epidermis.) These cells are at the bottom-most layer of our skin, where they divide to maintain a reservoir of epidermal stem cells, and also to provide the differentiated cells which make up our skin. Only a few years ago it was thought that our bodies contained only a very few stem cells, such as the ones for skin, the intestinal lining, or for blood cells. We now know that there are many more stem cells in our adult bodies, and that these cells can accomplish an astonishing range of tissue replenishments. And one distinct advantage of these adult stem cells is that we can use our own cells to regenerate tissue, totally circumventing the problem of immune rejection.

The variety of adult stem cells, as well as their range of replacement possibilities, is a fairly recent discovery, but the number of such existing cells and their potential continues to grow. One recent example is neural stem cells. Until recently the scientific dogma was that the brain and nerves did not replenish themselves. We now know that not only can they replenish themselves, but that these neural stem cells can "redefine" themselves, even forming blood cells!

Researchers have found that adult neural stem cells are as effective in reconstituting the immune system as fetal neural stem cells. In another study, workers found that they could "re-seed" the damaged brains of mice with adult neural stem cells, and these stem cells could multiply and repair the brains.

There is now evidence that stem cells are present in far more tissues and organs than once thought and that these cells are capable of developing into more kinds of cells than previously imagined. Efforts are now underway to harness stem cells and to take advantage of this new found capability, with the goal of devising new and more effective treatments for a host of diseases and disabilities.

Bone marrow stem cells seem to be one of the most adaptable of adult stem cells. These "stromal" (or "mesenchymal") cells are being developed commercially to treat numerous diseases and regenerate a wide range of tissues. Hematopoietic (blood-forming) stem cells from bone marrow as well as circulating blood have been used extensively in clinical applications with good success.

Generation of differentiated cell types from stem cells for tissue replacement.

All stem cells, no matter their source, are unspecialized cells that give rise to more specialized cells. Stem cells can become one of more than 200 specialized cells in the body. They serve as the body’s repair system by renewing themselves and replenishing more specialized cells in the body.

Cells (differentiated or multipotent stem cells) produce extracellular matrix proteins which - deposited in close proximity to the cells - provide a biomechanical scaffold (niche), serve as a harbour of growth factors and crosstalk with the cells via the receptors on the plasma membrane. These properties depend on the mixture of the matrix constituents.

Fibroblast growth factors are part of the extracellular matrix that are being used in vivo, in situ and in vitro to stimulate stem cells, hemopoiesis, the immune system, transplant donor cells, culture and/or engraftment.

The fibroblasts provide special factors that maintain the stem cells in their original state. Stem cell appears to be grasped by underlying fibroblasts. Also pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors.

Although the field of regenerative medicine is still in its infancy, researchers are already making regenerative methods a reality. As we learn more about how to harness the pathways of developmental biology, we will doubtless see more exciting developments in the field of regenerative medicine.

In the meantime we can use BIOSKINCARE. The biological ingredient in it has been proven to boost the proliferation of fibroblasts, and not only of those that remain healthy but also of senescent fibroblasts by a very significant factor.

The complex ingredient also contains a balanced mixture of natural factors that contribute to normalize and enhance the physiology of the skin.

Low molecular weight proteins that activate Fibroblast Growth Factor activity. Fibroblasts proliferation is key for they are the stem cells that give rise to new connective tissues: collagen and elastin fibers plus the glycosaminoglycans and proteoglycans that act as the glue that bind cells together and as fillers with a large capacity to withhold water many times their weight in water and give skin strength and elasticity.

High molecular weight proteins that work as Oxygen carriers (copper-haemocyanin)

Copper peptides that induce the degradation of "extra-large" collagen aggregates found in scars and promotes the synthesis of smaller more regular collagen as is normal skin

Enzymes, both with Collagenase and Gelatinase activities that degrade damaged proteins and tissues

Hyaluronic Acid, provides deep tissue hydration

Glycoproteins / mucopolysaccharides that act as signaling molecules and enhance communication among and within cells, thus coordinating an orchestrated process that recognizes damaged tissues, and activates the enzymes that "digest" or further degrade them into their amino-acid and other components, and uses those same components for the reconstruction of the extracellular matrix

Trace elements (Cu, Zn, Fe, Ca2+), some acting as coenzymes, necessary for Cellular Renewal,

Low molecular weight antioxidant compounds with Antioxidant & Anti-Inflammatory effects.

The tissue-regenerating effect of BIOSKINCARE is notable as it has been attested by studies done with a topical product including the biological ingredient at the Coaniquem Burn Center Foundation, a Non Profit Children's Burn Hospital in Santiago, Chile. Also confirmed by clinical studies done in Spain, where the ingredient in a topical formulation was applied for the treatment of burns, blisters and damage to skin due to radiotherapy to 100 patients undergoing radiotherapy or that had completed radiation treatment the previous month at the Ramon y Cajal Hospital in Madrid.

Moisturize, Protect, Repair and Renew Your Skin with BIOSKINCARE™ CREAM

A deeply moisturizing natural skin care cream. Triggers the regeneration of damaged cells while preventing and removing scars, keratosis, psoriasis scales and all types of skin blemishes. And replenishes the lipid barrier of the skin.