Uncommon organic activator of tissue healing & skin regeneration gives aging skin a refreshing outlook

Skin aging

In the natural replacement cycle of human skin, cells are continually being created, rising up through the epidermal layers to the surface and flaking off. A young skin renews its surface layers every 2 to 3 weeks. As we age abuse of daily life (such as solar radiation, stress, pollution, etc.) accumulates on our skin and cell production rate slows down causing the dead skin layer of the stratum corneum or surface to be thicker. Due to this obstruction old cells agglomerate and stay on the surface, interfering with tissue repair and slowing down cell regeneration.

There are several factors that cause the skin to age. Those factors can easily be classified into 3 main types: biological or intrinsic, environmental, and mechanical aging. These factors may be considered external o internal causes of skin deterioration. Let's look at each cause individually to understand ways they can be minimized.

Intrinsic aging

Natural or intrinsic aging is the result of changes-often genetically established-that happen naturally within the body. Everyone has a biological clock or chronological age established by his or her genetic makeup. As our biological clock ticks, our skin gradually loses its ability to function properly. This type of aging is a result of natural adjustments within the body that become visible signs of aging on the skin. Frequently, changes associated with biological aging are the result of a gradual shift in the balance of certain hormones and messenger molecules that are produced by other glands and organs within the body. Many of these modifications are genetically decided and cannot be controlled.

The most noticeable sign of intrinsic aging is a lessening in the overall thickness of the epidermis with a reduction in the number of cellular layers. The amount of cells in the stratum corneum, however, do not decrease with age. This is important because of its role as a skin barrier. On the other hand, the amount of melanocytes, Langerhans cells, and other cells do decline with age. Langerhans cells are related to the body's response to allergens. This explains why some people seem to experience fewer allergic reactions as they grow older.

The inward projections of the epidermis into the skin, or rete pegs, become less pronounced and the junction of the dermis and epidermis become flattened. This means that the epidermis is not so firmly held down and is more exposed to injuries that may be caused by friction. The skin's metabolism and the speed at which epidermal cells are produced slow down, which may interfere with wound healing. In other words, the time necessary to heal the stratum corneum barrier increases considerably with age denoting that skin cell replacement will take twice as long for people over 75 than for those over 30.

Even though the sebaceous glands themselves do not change much with advanced age, facial glands become larger while sebum production fades in older people, mainly those over 70. The amount of active sweat glands falls, reducing sweat output. As a result, perspiration is less in elderly skin. This helps understand why older people often find it hard to get used to hot weather.

Most elderly people have dry skin and therefore have a marked need to minimize the over-use of harsh soaps and detergents, in order to avoid problems associated to dryness. Aged skin retains its basic ability to control water loss, but may partially lose this capacity if the stratum corneum barrier becomes damaged by physical or chemical agents. This makes the skin vulnerable to several substances that will attack aged skin more easily than they would younger skin.

Luckily, some of the elements contributing to biological aging can be regulated. Scientists are starting to comprehend how free radicals (unstable molecules) alter proteins, lipids, and the DNA inside the cells, and, in turn, accelerate the biological aging process. Antioxidants are molecules with the ability to nullify free radicals found in the skin. A healthy diet full of antioxidant-rich fruits and vegetables, along with nutritional supplements and topical application of key nutrients, can help delay the onset of many biological changes and decrease their strength.

External agents that affect how skin ages

The second group of factors that make the skin age prematurely are all results of external agents in the environment. Environmental aging occurs as a result of daily exposure to trillions of free radicals from various sources: the sun's ultraviolet radiation, pollution, smoke, adverse weather, and external stress. These free radicals damage lipids, proteins, and DNA, all of which restrict the cell's ability to work properly, and cripple the integrity of overall cell composition. Years of accumulated environmental stress on cellular structures results in early skin aging.

Solar exposure is the main environmental stressor leading to damaged skin. The damage to the skin's structure caused by both constant and occasional exposure is called photoaging. Even though other factors such as cigarette smoke, exposure to adverse weather conditions, and pollution are profuse aids to environmental aging, UV damage from the sun's radiation accounts for 90% of all early skin aging. Photoaging damages melanocytes, elastin, collagen, and the moisture barrier, resulting in dark spots, wrinkles, sagging, uneven skin tone, and a rough, dry skin texture.

While solar exposure is the environmental stressor that accounts for most early skin aging, there are others. Pollution damages skin by boosting free radical production. Harsh weather, dry air, wind, and cold drain skin of essential moisture, resulting in a rough texture and thin, dry lines. Cigarette smoke elevates free radical production and may decrease collagen and elastin synthesis. Cigarettes also significantly decrease the supply of oxygen to the cells.

Mechanical aging

The third and final type is called mechanical aging. Mechanical aging is the result of constantly repeated wrinkle causing gestures, muscular movements that are done day after day and year after year. Even though it is unrealistic to avoid some wrinkle causing gestures such as smiling or frowning, we have made a list of behaviours that should be avoided:

Squinting.
The thinker pose (resting chin or cheek in hand).
Sleeping on your side or stomach.
Scrubbing with hot water.
Weight changes.
Unbalanced diet and lack of sleep.
Pursing the lips when smoking or drinking from a straw.

Evidence of Aging: Changes in Physiology Skin aging derives from the degeneration of structures in the skin and the slowing down of its functions. Let's take a closer look at various patent signs of aging and what occurrs inside the skin to cause these changes.

Normal, young skin keeps appropriate moisture levels through the sealing properties of the moisture barrier, which is composed of keratin-filled keratinocytes (skin cells) surrounded by and sealed together with interspersed epidermal lipids (ceramides, lipids, and fatty acids). As we age, the skin synthetizes fewer ceramides, lipids, and fatty acids to secure the moisture barrier, resulting in an increase in transepidermal water loss and dryness. A natural lessening in hormone levels is usually the cause of this reduced production; however, various other preventable factors can also strip epidermal lipids. Consider the following:

Improper skin care. Using harsh cleansers and forgetting to supplement the skin with suitable, nourishing moisturizers.
Harsh weather conditions. Enduring extreme temperatures and wind with no adequate moisturizers or protection.
UV rays. Neglecting to shield skin from the solar ultraviolet radiation with sunscreen.

In healthy skin new cells are carried to the surface as superficial cells are constantly shed. The skin cells at the lower layer of the epidermis (stratum basale) continually divide, forming new keratinocytes. This reconstructive mechanism is called skin cell rejuvenation. As we age, the speed of rejuvenation decreases, causing cells to become more "sticky" and not shed as easily. As a result, the skin turns thinner and more vulnerable to environmental harm, especially photodamage produced by the sun's ultraviolet radiation. Eventually, the skin becomes dull and coarse in texture.

There are various factors that help the decline of skin cell rejuvenation as we age. For example, deteriorated blood vessels in the dermis and a flattening of dermal papillae reduces the surface region between the dermis and epidermis across which nutrients can disperse. This process reduces nutrient and oxygen supplies to the basal cells in the lower epidermis. UV exposure can also penetrate the skin, damage basal cells, and slow down the speed of cell division. Lastly, failure to exfoliate the surface of the skin with mechanical and chemical exfoliates contributes to the drop in renewal.

A third evident sign of aging is fine lines and deep wrinkles in the skin. The structural protein called collagen, which is found in the dermis, gives a mesh-like foundation of support and strength for the skin. As we age, collagen synthesis decreases and collagen fibers degrade at a faster speed than in earlier years. This results in an overall decrease in the amount of collagen in the dermis. Areas with little support begin to cave in and wrinkles begin to form.

Multiple factors lead to decreased collagen levels. Firstly, age causes a natural decline in messenger molecules that triggers collagen synthesis and stimulates an increase in the enzyme collagenase which downgrades collagen. Another conducing factor are free radicals from ultraviolet exposure. These can harm collagen strands and promote collagenase activity, which leads to the creation of irregular collagen linkages which weaken the skin. In order to prevent ultraviolet damage to collagen fibers and fibroblasts, application of a constant daily sunscreen is necessary. Research has shown that chemical exfoliation may promote collagen synthesis.

The following are factors that decrease collagen reserves in the skin:

UV radiation can penetrate the skin and cause damage to collagen leading to the synthesis of fibroblast cells.
Mechanical stress on the skin caused by persistant actions that produce wrinkling can also break down collagen.
With age, the production of glycosaminoglycans (GAGs) decreases, affecting moisture levels in the dermis; collagen turns fragile and prone to breakage.
As skin rejuvenation decreases, wounds heal more slowly and the skin weakens, becoming more vulnerable to environmental stressors; this can lead to damaged fibroblasts and a decline in collagen levels.

All 3 types of skin aging -biological, environmental, and mechanical- contribute to the skin's deterioration. Biologically, our body naturally produces more of the DHT hormone as we age. As DHT levels rise, elastin synthesis is restricted. Elastin is another structural protein found in the dermis. This coil-like protein has the capability of snapping back into place after stretching, giving the skin its elastic quality. With age, elastin fibers surrender much of their resilience along with elastin synthesis within the decline of the fibroblasts. This overall decline in normal elastin levels results in areas of reduced firmness, especially along the jaw line, neck, and around the eyes. Environmentally, ultraviolet radiation can penetrate the skin and harm elastin-synthesizing fibroblast cells. As skin cell rejuvenation decreases, injuries heal more slowly and the skin weakens, becoming more vulnerable to environmental damage. This can lead to damaged fibroblasts and reduced elastin levels. Finally, mechanical stress, due to repeated wrinkle causing behaviors, can forever stretch out elastin fibers.

Another noted sign of aging are enlarged pores. To a large degree, pore size is settled by genetics; but as we age, they tend to appear larger. Its enlarged aspect is due basically to a buildup of dead cells surrounding the pore. As more collagen is broken down and synthesis slows, the supportive structures surrounding cells decrease and cells can appear stretched. Keeping the skin exfoliated and the pores clear will help decrease the appearance of pore size. Another recommendation is to constantly use a sunscreen to shield collagen.

Age spots are the last sign of aging that we're going to discuss. Normal skin pigmentation contributes to protect normal skin from the stress of moderated ultraviolet exposure. Melanin, the skin's photoprotective agent, is synthesized in specialized melanocyte cells in the deepest layer of the epidermis (stratum basale). As we age, melanocyte functionality diminishes, making the skin more vulnerable to ultraviolet damage. With age, melanocytes also tend to cluster together. This produces patches of pigmentation called age spots.

Many factors contribute to the appearance of age spots. First, hormone imbalances that occur with advanced age result in fewer melanocytes and can also stimulate extreme melanin synthesis. Second, ultraviolet light rays stimulate melanocytes to synthesize skin pigmentation. UV light can also break through the skin and harm melanocyte DNA, which can stimulate melanocytes to become larger and cluster together. Third, as the cell renewal cycle decreases, wounds heal more slowly and the skin weakens, becoming more vulnerable to environmental damage. This can lead to damaged melanocytes and abnormal pigmentation. Finally, poor skin care habits can lead to skin irritation, which trigger melanin synthesis.

As we age cell rejuvenation slows down. Our skin begins to look dull, with an uneven thickened texture. In some cases, our face can look uneven, due to dead skin cells that have built up on the surface. The reduction of the renewal process is especially marked between the ages of 25-30,however, it is advised to begin exfoliating even before the age of 30. We mustn't forget that a metropolitan lifestyle and contact with pollutant particles can negatively affect cell replacement.

Air pollution not only endangers our health but also our looks!

Every day, air pollution damages plants and buidings - and obviously, our skin. The presence of oxides, hydrocarbons and traces of heavy metal, specially iron, impedes natural epidermal respiration, damaging the skin's natural protective film and inducing the production of free radicals, which accelerate cell aging.

This is why the amount of people who are affected by hypersensitivity and allergic reactions - even at a young age - continues rising.

Debilitated, sensitive skin with a tendency to blush easily; problems with fragile capillaries, irritability or even allergies. Dry, dehydrated skin, sometimes with a tendency towards oiliness.

These are the characteristics of hypersensitive skin, and dermatologists have noted a constant rise in the amount of people with these symptoms.

There is a continual need to replace worn out or damaged cells, however, the field of regenerative medicine is still in its inicial stages and we are yet to enjoy its benefits. Luckily enough, you can turn back the clock. Even if in the past you did not adequately care for your skin, we can help restore solar damaged skin and reverse some of the effects of both biological and mechanical aging. A youthful glow begins with good skin care.

Prevent Premature Skin Aging with a Proper Skin Care Routine

BIOSKINCARE is apt not only for mature skin, but also for younger skin. Its ENZYMES cleanse, getting rid of harmful substances. It also rises the flow of oxygen to the skin and stimulates cellular metabolism, neutralizing the corrosive effects of pollutants, stimulating cell respiration and delaying the skin's aging process.

The biological ingredient in BIOSKINCARE has been demonstrated to boost the creation of old and new fibroblasts.

BIOSKINCARE is a 100% clean, natural skincare cream that stimulates the skin's regenerative ability and accelerates skin cell restoration or turnover, thus replacing dead cells with fresh cells that are pushed to the skin's surface, leaving the outer epidermal layer or stratum corneum softer and naturally hydrated, thereby conferring the skin a younger-looking appearance.

Freckles and age spots start to disappear. Pigment cells (melanin) become more uniformly distributed, helping to avoid the presence of new blemishes and age spots - even scars that you have lived with for a long time appear thinner and less evident. The skin becomes richer in water holding molecules, collagen, and elastin which increase resilience and firmness. All these factors work together to keep skin looking and feeling younger.

BIOSKINCARE increases cellular replacement of abundant, healthy keratinocytes, pushing fresh cells to the surface more quickly and helping old cells to exfoliate faster
Controls melanocyte synthesis reversing and avoiding hyperpigmentation
Stimulates the uniform distribution of melanin, eliminating unwanted dark patches and age spots
Stimulates fibroblasts, the cells that produce collagen and elastin, for a stronger, more resilient skin
Raises GAG production, providing natural hydration and vital nutrients to the epidermis
Increases microcirculation and the creation of new healthy blood vessels, improving blood circulation and oxygenation of the skin

What is the mysterious component in Bioskincare that produces such wonderful results?

BIOSKINCARE is made with the ONLY element found in NATURE created by a tiny creature which produces a serum endowed with the ability to (1) deal with daily exposure to trillions of free radicals from a variety of different sources: solar ultraviolet radiation, pollution, severe weather conditions, and external stress; (2) keep its skin permanently moisturized, and; (3) regenerate its skin and even parts of some of its other organs whenever damaged.

In order to moisturize, protect, heal and renew skin this tiny creature makes a liquid that it expels onto its skin. Scientific research has identified the fluid as a complex compound of glyco or sugar chain molecules bound to proteins, peptides, enzymes, co-enzymes and oligoelements with strong biological activity. The same molecules are found in human skin when skin is damaged, particularly in younger people, where skin injuries heal quickly and with no aberrant scars, however, in adults these molecules are scarce or present themselves in insufficient proportions.

This fluid is taken from live organisms of the Phylum mollusc family, which belongs to the class of gastropoda, and Helix Aspersa Müller species, or better known as the modest brown garden snail. By using proprietary technology, no damage is done to the snails during the labor-extensive recollection process.

It is this same fluid that shields the snail's body from oxygen radicals that often attack it when it comes out of its shell after hibernating. It also protects the snail's body from the effects of ultraviolet solar rays and from opportunistic micro-organisms always ready to invade when the skin is damaged.

But, what is far more important to humans, is that these little creatures happen to have a skin made-up of the same structural components as that of human skin: elastin, water holding molecules, collagen, etc. Therefore the liquid produced by the snail is capable of protecting and repairing our skin.

The skin is a constantly self-renewing organ, with a complex, multilayered kinetic structure. The epidermis contains mainly keratinocytes, along with a minor concentration of nervous cells, stem cells, and maybe a pool of quiescent cells (a dormant reservoir). As we age renewal slows down so it's time to activate skin renewal with a little help. And there's no better way to do this then by supporting the process with a biological cream that is compatible with living cells.

Moisturize, Protect, Repair and Renew Your Skin with BIOSKINCARE™ CREAM

A deeply moisturizing natural skin care cream. Triggers the regeneration of damaged cells while preventing and removing scars, keratosis, psoriasis scales and all types of skin blemishes. And replenishes the lipid barrier of the skin.